Non-surgical methods of abortion have the potential to advance the quality and safety of women’s reproductive health in the developing era.

However, until lately, the utilization and availability of medical abortion with Mifeprex and Misoprostol is increasing day by day. In this respect, this blog provides the usage, and difference in the effectiveness of the two regimens.

What is Mifeprex?

Mifeprex is an anti-progesterone which helps in the termination of the pregnancy by blocking the hormone called progesterone. Progesterone is very important in pregnancy, it helps to provide nutrition to the embryo and helps it to develop inside the womb. So by blocking the hormone, the pregnancy ends there. Mifeprex is also available in 2 generic form that is Mifepristone and Generic RU486. The working mechanism and dosage strength are similar to the generic versions. Mifeprex is available in 200 mg. 

What is Misoprostol?

Misoprostol is a synthetic prostaglandin E1 analog which is used in medication abortion that causes softening of cervical and uterine contractions. So this medicine helps to cause contractions and pass out the embryo with the help of vaginal bleeding. Misoprostol is also available in generic forms that are Cytolog and Cytotec. This pill is available in 800 mcg strength which is similar in other generic versions.

What is the dosage pattern of the Mifeprex and Misoprostol pills?

The dosage pattern is very simple and one can easily take the abortion pills at their home in privacy to terminate the pregnancy, medical abortion is similar to a natural miscarriage so women may experience vaginal bleeding and cramps for few days.

The first step is to take Mifepristone 200 mg orally and then wait for 24-48 hours and take Mifepristone 800 mcg. This medication can be taken orally or buccally whichever method you find it more convenient.  

After you consume both the pill you may experience severe cramps and vaginal bleeding may start soon after 2-24 hours.

What is the difference between Mifeprex and Misoprostol?

Mifepristone and Misoprostol have some minute difference which is discussed below:

1- Mifeprex is used to hinder the progesterone and Misoprostol is taken to soften the uterus and allow the pregnancy to pass with the help of bleeding

2- Mifeprex is required to be taken orally with water. And Misoprostol can be taken in 2 methods one is buccal and the other is vaginal. If you are taking it buccally then you have to place 4 pills of Misoprostol of 200 mcg in your cheek pouches or beneath your tongue for 30 minutes till it gets melt completely and another method is vaginally where you have to insert the pills in the vaginal area. 

3- Mifeprex just blocks the pregnancy whereas Misoprostol causes contractions and helps to flush out the pregnancy.

4- The combination of both medicines is 99% effective whereas Mifepristone and Misoprostol alone are 70% effective.

Thus, this study provides an important possibility to better understand the real difference and the benefits of these 2 non-surgical abortion regimens.